A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes

We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating sensory transmission from peripheral afferents into the rat spinal cord. Subunit-specific antibodies reveal high levels of SK3 immunoreactivity in laminas I, II, and III of the spinal cord. Among dorsal root ganglion neurons, both peripherin-positive (C-type) and peripherin-negative (A-type) cells show intense SK3 immunoreactivity. Furthermore, dorsal root-stimulated sensory responses recorded in vitro are inhibited when SK channel activity is increased with 1-ethyl-2-benzimidazolinone (1-EBIO). In vivo electrophysiological recordings show that neuronal responses to naturally evoked nociceptive and nonnociceptive stimuli increase after application of the selective SK channel blocker 8,14-diaza-1,7( 1,4)-diquinolinacyclotetradecaphanedium ditrifluoroacetate (UCL 1848), indicating that SK channels are normally active in moderating afferent input. Conversely, neuronal responses evoked by mechanical stimuli are inhibited when SK channel activity is increased with 1-EBIO. These effects are reversed by the subsequent application of UCL 1848. Our data demonstrate that SK channels have an important role in controlling sensory input into the spinal cord

A procedure for the change point problem in parametric models based on phi-divergence test-statistics

This paper studies the change point problem for a general parametric, univariate or multivariate family of distributions. An information theoretic procedure is developed which is based on general divergence measures for testing the hypothesis of the existence of a change. For comparing the accuracy of the new test-statistic a simulation study is performed for the special case of a univariate discrete model. Finally, the procedure proposed in this paper is illustrated through a classical change-point example

Changes in ambient air pollutants in New York State from 2005 to 2019: Effects of policy implementations and economic and technological changes

Over the past 20 years, a number of regulatory efforts have been applied to improve air quality in the United States and specifically in New York State. These measures generally focused on mobile emissions through emissions controls and improved fuel quality, and controls on electricity generation to reduce emissions from older, uncontrolled electricity generation units (EGUs). In addition, economic drivers such as the major recession in 2007–2009 and the change in the relative costs of natural gas and coal also drove changes in the mixture of EGU technologies. To assess the effects of these changes and to define the baseline for future changes as the economy further decarbonizes through renewable electricity generation and electric vehicles, the concentrations of all pollutants measured at all regulatory monitoring sites in New York State were assessed for their trends. Trends were examined using seasonal-trend decomposition with local regression smoothing (STL), Mann-Kendall trend analysis with the Theil-Sen nonparametric slope estimation, and piecewise regression analysis to identify breakpoints in the slopes of the time series data. The concentrations of primary gaseous pollutants, CO, NO2, and SO2 have decreased substantially in step with the declining emissions. PM2.5 has substantially declined largely due to the reductions in particulate sulfate. However, in recent years, the rate of decline has diminished due to relatively constant or increasing particulate nitrate and secondary organic aerosol. O3 has also generally increased at the urban sites likely as a result of reduced NOx emissions, while it declined or remained constant at the rural sites. Thus, the promulgated regulations assisted by the economic drivers have improved air quality, but additional actions will be needed to further reduce urban O3 and PM2.5

3D modelling of angiogenesis and vascular tumour growth

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

A new approach to cure and reinforce cold-cured acrylics

Purpose: The low degree of polymerization of cold-cured acrylics has resulted in inferior mechanical properties and fracture vulnerability in orthodontics removable appliances. Methods: In this study, the effect of reinforcement by various concentrations of chopped E-glass fibers (0%, 1%, 2%, 3% and 5% by weight of resin powder) and post-curing microwave irradiation (800 W for 3 min) on the flexural strength of cold-cured acrylics was evaluated at various storage conditions (at room temperature for 1 day and 7 days; at water storage for 7, 14 and 30 days). Results: The data was analyzed by using 1-way and 2-way ANOVA, and a Tukey post hoc test (α = .05). The specimens with chopped E-glass fibers treated with post-curing microwave irradiation significantly increased the flexural strength of cold-cured PMMA. The optimal concentration might be 2% fibers under irradiation. Conclusions: The exhibited reinforcement effect lasted in a consistent trend for 14 days in water storage. A new fiber-acrylic mixing method was also developed. © 2012 The Author(s).published_or_final_versio

A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery

published_or_final_versio

VLSI Architectures for the Steerable-Discrete-Cosine-Transform (SDCT)

Since frame resolution of modern video streams is rapidly growing, the need for more complex and efficient video compression methods arises. H.265/HEVC represents the state of the art in video coding standard. Its architecture is however not completely standardized, as many parts are only described at software level to allow the designer to implement new compression techniques. This paper presents an innovative hardware architecture for the Steerable Discrete Cosine Transform (SDCT), which has been recently embedded into the HEVC standard, providing better compression ratios. Such technique exploits directional DCT using basis having different orientation angles, leading to a sparser representation which translates to an improved coding efficiency. The final design is able to work at a frequency of 188 MHZ, reaching a throughput of 3.00 GSample/s. In particular, this architecture supports 8k UltraHigh Definition (UHD) (7680 × 4320) with a frame rate of 60 Hz, which is one of the best resolutions supported by HEVC

Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box.

An accommodation-free displays, also known as Maxwellian displays, keep the displayed image sharp regardless of the viewer's focal distance. However, they typically suffer from a small eye-box and limited effective field of view (FOV) which requires careful alignment before a viewer can see the image. This paper presents a high-quality accommodation-free head mounted display (aHMD) based on pixel beam scanning for direct image forming on retina. It has an enlarged eye-box and FOV for easy viewing by replicating the viewing points with an array of beam splitters. A prototype aHMD is built using this concept, which shows high definition, low colour aberration 3D augmented reality (AR) images with an FOV of 36°. The advantage of the proposed design over other head mounted display (HMD) architectures is that, due to the narrow, collimated pixel beams, the high image quality is unaffected by changes in eye accommodation, and the approach to enlarge the eye-box is scalable. Most importantly, such an aHMD can deliver realistic three-dimensional (3D) viewing perception with no vergence-accommodation conflict (VAC). It is found that viewing the accommodation-free 3D images with the aHMD presented in this work is comfortable for viewers and does not cause the nausea or eyestrain side effects commonly associated with conventional stereoscopic 3D or HMD displays, even for all day use

Chinese patients with sporadic Hirschsprung's disease are predominantly represented by a single RET haplotype.

published_or_final_versio

The effect of ionic composition on acoustic phonon speeds in hybrid perovskites from Brillouin spectroscopy and density functional theory

© The Royal Society of Chemistry 2018. Hybrid organic-inorganic perovskites (HOIPs) have recently emerged as highly promising solution-processable materials for photovoltaic (PV) and other optoelectronic devices. HOIPs represent a broad family of materials with properties highly tuneable by the ions that make up the perovskite structure as well as their multiple combinations. Interestingly, recent high-efficiency PV devices using HOIPs with substantially improved long-term stability have used combinations of different ionic compositions. The structural dynamics of these systems are unique for semiconducting materials and are currently argued to be central to HOIPs stability and charge-transport properties. Here, we studied the impact of ionic composition on phonon speeds of HOIPs from Brillouin spectroscopy experiments and density functional theory calculations for FAPbBr3, MAPbBr3, MAPbCl3, and the mixed halide MAPbBr1.25Cl1.75. Our results show that the acoustic phonon speeds can be strongly modified by ionic composition, which we explain by analysing the lead-halide sublattice in detail. The vibrational properties of HOIPs are therefore tuneable by using targeted ionic compositions in the perovskite structure. This tuning can be rationalized by non-trivial effects, for example, considering the influence of the shape and dipole moment of organic cations. This has an important implications for further improvements in the stability and charge-transport properties of these systems